BOOST+ was formulated based on peer-reviewed research and scientific studies, including both non-clinical and clinical trials.

Effects of Berry Anthocyanins on Cognitive Performance, Vascular Function and Cardiometabolic Risk Markers: A Systematic Review of Randomised Placebo-Controlled Intervention Studies in Humans

A systematic review found that supplementation with berry-derived anthocyanins was associated with improvements in memory, and some evidence for improved attention, psychomotor speed or executive function; vascular function (e.g., flow-mediated dilatation) and blood-pressure also showed favourable changes.

Wild Blueberry Extract Intervention in Healthy Older Adults

In healthy older adults, a randomized controlled multi-study found that wild blueberry extract produced modest improvements in cognitive outcomes (especially during post-lunch cognitive dips) and potential cardiovascular benefits.

The Effect of Long-Term Aronia melanocarpa Extract Supplementation on Cognitive Performance and Blood Pressure in Individuals at Risk of Cognitive Decline

A 24-week intervention using Aronia melanocarpa extract in at-risk adults demonstrated improved psychomotor speed and reductions in diastolic blood pressure (for higher dose), indicating a link between vascular health and cognition.

A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract in Maintenance of Episodic and Working Memory in Older Adults.

Older adults who consumed low dose wild blueberry powder or extract showed improvements in episodic memory compared to placebo, supporting berry-derived polyphenol benefits for brain function.

Effects of the Active Botanical Blend “WKUP GT” on Attention, Memory, Psychomotor and Executive Function Tasks.

A randomized, double-blind, placebo-controlled study examined a botanical blend containing guarana, elderberry and green tea extracts. Results showed significant improvements in attention, memory, psychomotor speed, and executive function — without increasing heart rate or blood pressure.

Polyphenol-rich Tart Cherries (Prunus Cerasus, cv Montmorency) Improve Sustained Attention, Feelings of Alertness and Mental Fatigue and Influence the Plasma Metabolome in Middle-aged Adults: A Randomised, Placebo-Controlled Trial.

A randomized, placebo-controlled trial found that supplementation with Montmorency tart cherries improved sustained attention, enhanced alertness, and reduced mental fatigue in middle-aged adults, along with changes in plasma metabolome.

Efficacy of Vitamins on Cognitive Function of Non-Demented Middle-aged or Older People: A Systematic Review and Meta-Analysis.

A systematic review of randomized or quasi-randomized trials found that B vitamins taken for more than three months were associated with modest improvements in global cognition and episodic memory in non-demented middle-aged or older adults.

B Vitamins and Prevention of Cognitive Decline and Incident Dementia: A Systematic Review and Meta-Analysis.

This meta-analysis found that B-Vitamin Supplementation (including folate, B6, and B12) was associated with slower cognitive decline in older adults without dementia, particularly in interventions lasting more than 12 months.

Effects of Anthocyanins on Cognition and Vascular Function: A Systematic Review.

A systematic review of randomized controlled trials found that anthocyanin intake led to positive effects on verbal and working memory (supported by imaging of brain blood-flow) though the effects on blood pressure and other vascular markers were inconsistent.